TNF -> TNFR apoptosome -> CASP3 XIAP -| CASP3 MOMP -> SMAC TNFR -> DISC_TNF FADD -> DISC_TNF CASP8 -> BAX BCL2 -| BAX RIP1 -> RIP1ub cIAP -> RIP1ub BCL2 -| MPT ROS -> MPT FASL -> DISC_FAS FADD -> DISC_FAS RIP1 -> RIP1k DISC_TNF -> CASP8 DISC_FAS -> CASP8 cFLIP -| CASP8 CASP3 -> CASP8 ATP -| NonACD RIP1ub -> IKK CASP8 -| RIP1 TNFR -> RIP1 DISC_FAS -> RIP1 MPT -| ATP SMAC -| cIAP cIAP -> cIAP NFkB -> cIAP NFkB -> cFLIP RIP1k -> ROS MPT -> ROS NFkB -| ROS SMAC -| XIAP NFkB -> XIAP IKK -> NFkB CASP3 -| NFkB BAX -> MOMP MPT -> MOMP CASP3 -> apoptosis Cyt_c -> apoptosome ATP -> apoptosome XIAP -| apoptosome NFkB -> survival MOMP -> Cyt_c NFkB -> BCL2 $ATP: !MPT $BAX: (CASP8 & !BCL2) $BCL2: NFkB $CASP3: (apoptosome & !XIAP) $CASP8: (((DISC_TNF & !cFLIP) | (CASP3 & !cFLIP)) | (DISC_FAS & !cFLIP)) $Cyt_c: MOMP $DISC_FAS: (FASL & FADD) $DISC_TNF: (TNFR & FADD) $IKK: RIP1ub $MOMP: (BAX | MPT) $MPT: (ROS & !BCL2) $NFkB: (IKK & !CASP3) $NonACD: (!ATP | !ATP) $RIP1: ((DISC_FAS & !CASP8) | (TNFR & !CASP8)) $RIP1k: RIP1 $RIP1ub: (cIAP & RIP1) $ROS: ((MPT & !NFkB) | (RIP1k & !NFkB)) $SMAC: MOMP $TNFR: TNF $XIAP: (NFkB & !SMAC) $apoptosis: CASP3 $apoptosome: ((Cyt_c & ATP) & !XIAP) $cFLIP: NFkB $cIAP: ((cIAP & !SMAC) | (NFkB & !SMAC)) $survival: NFkB